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Understanding Acne Aids in Treatment

Posted on December 31, 2009
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WASHINGTON — Understanding the pathogenesis of acne better equips physicians to manage the disorder and educate patients, Dr. Richard J. Antaya advised at the annual meeting of the American Academy of Pediatrics. (Source: Pediatric News)

Evaluation of the Antibacterial Activity of Rhapontigenin Produced from Rhapontin by Biotransformation against Propionibacterium acnes.

Posted on December 31, 2009
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Authors: Kim JK, Kim N, Lim YH Biotransformation is often used to improve chemical activity. We evaluated the antimicrobial activity of rhapontigenin, converted from rhapontin after treatment with Pectinex. Rhapontigenin showed 4-16 times higher antimicrobial activity than rhapontin. Activity was higher against Gram positive strains than Gram negative strains. Minimum inhibitory concentrations (MICs) of rhapontigenin, retinol, and five antibiotics were determined by microbroth dilution method for antibiotic-sensitive and -resistant Propionibacterium acnes. We also investigated the in vitro antibacterial activity of rhapontigenin in combination with antibiotic against antibiotic-resistant P. acnes. The antibiotic combination effect against resistant P. acnes was studied by checkerboard ...

[Severe drug hypersensitivity reaction (DRESS syndrome) to doxycycline.]

Posted on December 31, 2009
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CONCLUSION: This patient is the third case of DRESS to doxycycline described in the literature. The originality of this case lies in the allergological investigation using patch-tests and HLA determination. PMID: 20110067 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

In vitro activities of azole antifungal agents against Propionibacterium acnes isolated from patients with acne vulgaris.

Posted on December 31, 2009
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Authors: Sugita T, Miyamoto M, Tsuboi R, Takatori K, Ikeda R, Nishikawa A The Gram-positive bacterium Propionibacterium acnes is the causative agent of acne vulgaris. Antibiotics such as tetracycline and macrolide derivatives are used to treat this skin disease; however, the isolation frequency of antibiotic-resistant P. acnes has been increasing. The anti-P. acnes activity of imidazole antifungal agents was reported more than 20 years ago, and since then, new azole antifungal agents have been marketed. Thus, this study determined the in vitro activities of azole antifungal agents against P. acnes isolated from patients with acne vulgaris. Of the five agents tested, miconazole, ketoconazole, and itraconazole showed concentration-dependent anti-P. acnes activity, including against antib...

Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes

Posted on December 30, 2009
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This study suggests that DHT may not only be involved in sebum production but also in production of proinflammatory cytokines in acne. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00403-009-1019-6Authors Weon Ju Lee, Kyungpook National University School of Medicine Department of Dermatology 200, Dongduk-ro, Jung-gu Daegu Republic of KoreaHong Dae Jung, Kyungpook National University School of Medicine Department of Dermatology 200, Dongduk-ro, Jung-gu Daegu Republic of KoreaSeong Geun Chi, Kyungpook National University School of Medicine Department of Dermatology 200, Dongduk-ro, Jung-gu Daegu Republic of KoreaByung Soo Kim, Kyungpook National University School of Medicine Department of Dermatology 200, Dongduk-ro, Jung-gu Daegu Republic of KoreaSeok-Jong Lee, Kyung... keep looking »